Question 1

Is Cardarine legal in Canada?

Accepted Answer

Cardarine (GW-501516) is not an approved drug or licensed health product in Canada and carries no Health Canada authorization for human use. It can be sold and purchased as a research chemical for laboratory and educational purposes only, but it is not legal to market or use for human consumption. It is also banned at all times in sport by WADA.

Question 2

Is Cardarine a SARM?

Accepted Answer

No. Although it is commonly discussed within the Canadian SARMs market, Cardarine is a selective PPARδ agonist with no androgenic or hormonal activity. It works through a nuclear receptor that controls lipid metabolism and energy expenditure, which is a completely different mechanism from true androgen-receptor SARMs like LGD-4033 - Ligandrol.

Question 3

Why did GSK stop developing GW-501516?

Accepted Answer

GlaxoSmithKline discontinued the compound after long-term (two-year) rodent carcinogenicity studies showed dose-dependent tumours across numerous organs. Supporting mechanistic work also showed PPARδ activation accelerating metastatic cancer in carcinogen-exposed mice.5 It was never approved for human use.

Question 4

What is Cardarine researched for?

Accepted Answer

In the scientific literature it is studied as a model PPARδ agonist for fatty-acid oxidation, endurance and exercise-mimetic biology,2 and for its effects on blood lipids such as HDL-C and triglycerides.4 Because of its metabolic focus it is often compared with SR9009 - Stenabolic in pathway research.

Agonistes du PPARδ

Cardarine - GW-501516