Complete your stack
- MK2866 - Ostarine $99.99
- SR9009 - Stenabolic $99.99
- Cardarine - GW-501516 $109.99
RAD 140 – Testolone
$109.99
- Best For: Bulking, strength, muscle density
- Recommended Dosage: 10–20 mg per day
- Cycle Length: 8–12 weeks
- PCT Required: Yes
RAD-140 (Testolone) is a potent SARM crafted to boost strength, muscle mass, and endurance while offering a safer alternative to traditional anabolic steroids.
Description
When a research protocol calls for testosterone-level anabolic signalling without the estrogen conversion or the broad organ exposure of traditional anabolic steroids, RAD-140 (Testolone) is the selective androgen receptor modulator most Canadian labs reach for first. In the preclinical work that introduced it, RAD-140 drove pronounced muscle-building activity while largely sparing the prostate. That is one of the most tissue-selective anabolic profiles ever reported for a SARM.1
What Is RAD-140 (Testolone)?
RAD-140, also known by the research name Testolone, is an orally bioavailable, non-steroidal selective androgen receptor modulator (SARM) first characterised by Miller and colleagues at Radius Health in 2010.1 Like all SARMs, it binds the androgen receptor (AR) and switches on the same anabolic programs as testosterone in muscle and bone, while producing far weaker activity in tissues such as the prostate. That selectivity is the whole point of the molecule, and it is why RAD-140 has become a benchmark reference material for musculoskeletal and oncology research, including here in Canada.
How RAD-140 Works
Testosterone and other classical androgens act on the androgen receptor everywhere it is expressed, which is why they build muscle but also drive prostate growth, water retention and estrogen-related effects. RAD-140 was engineered to behave as a strong AR agonist in anabolic tissue and a much weaker one elsewhere. In the original rodent models it produced muscle (levator ani) growth comparable to testosterone while stimulating the prostate only a fraction as much, which gives it an anabolic-to-androgenic ratio far higher than testosterone itself.1 Because it is not a substrate for aromatase, it does not convert to estrogen.
What the Research Shows
- Muscle & bone. Preclinical models report increased lean mass and bone mineral density with RAD-140 exposure. Those are the properties that first made it a candidate for age-related muscle wasting.13
- Hormone-driven cancers. In androgen/estrogen receptor-positive breast-cancer models, oral RAD-140 suppressed tumour growth through a distinct AR-mediated mechanism, and it has since been investigated clinically in that setting.2
- Tissue selectivity. Across these studies the recurring theme holds: robust anabolic signalling with a comparatively small androgenic footprint.1
RAD-140 is frequently studied alongside other SARMs. Researchers comparing recomposition endpoints often run it next to LGD-4033 (Ligandrol) for mass or Ostarine (MK-2866) for a milder profile, and pair it with Cardarine (GW-501516) when endurance is the endpoint.
Chemical Properties
| Research Name | RAD-140 (Testolone) |
| CAS Number | 1182367-47-0 |
| Molecular Formula | C20H16ClN5O2 |
| Molecular Weight | 393.83 g/mol |
| Classification | Non-steroidal selective androgen receptor modulator (SARM) |
Research Protocols & Handling
In published animal work RAD-140 is administered orally once daily, taking advantage of its long half-life. Reported research-model ranges sit well below the doses casually discussed in fitness circles. Helixx supplies RAD-140 strictly as a laboratory reference material, not for human or veterinary use. Store lyophilised or in-solution product cool, dry and out of direct light, and reconstitute with an appropriate solvent for your assay.
Potential Side Effects & Safety
Straight information matters more than hype. Because RAD-140 activates the androgen receptor, the effects documented in the research literature mirror those of other androgens:
- Hormonal suppression. AR agonism suppresses the body’s own testosterone and gonadotropin production; the SARM literature consistently notes suppression that requires a recovery period.
- Liver injury: the most important documented risk. Multiple peer-reviewed case reports describe cholestatic drug-induced liver injury after RAD-140 use, and the U.S. National Institutes of Health LiverTox database now catalogues SARM-associated hepatotoxicity.45 Injury has been severe in some reports and resolved on discontinuation in others.
- Lipids & cardiovascular markers. Androgen-receptor agonists commonly lower HDL cholesterol and can shift other cardiovascular markers.
RAD-140 is not approved for human consumption in Canada or elsewhere and is sold for research and educational use only. Anyone handling it should follow appropriate laboratory safety practices.
Frequently Asked Questions
Is RAD-140 legal in Canada?
RAD-140 is legal to buy and possess for research purposes in Canada. It is not approved by Health Canada for human use and cannot be sold as a supplement or for consumption, but it is not a controlled substance.
What makes RAD-140 different from anabolic steroids?
Traditional anabolic steroids activate the androgen receptor throughout the body and often convert to estrogen. RAD-140 is engineered for tissue selectivity: strong anabolic signalling in muscle and bone, weaker activity in the prostate, and no aromatisation to estrogen.1
How does RAD-140 compare to LGD-4033 or Ostarine?
What purity is Helixx RAD-140?
Every batch is third-party tested and supplied at ≥98% purity for laboratory research.
References
Peer-reviewed and authoritative sources cited above. Helixx supplies research materials for laboratory and educational use only; citations are provided for independent verification, not as medical guidance.
- Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010;2(2):124–129. PMID: 24900290.
- Yu Z, He S, Wang D, et al. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor–Positive Breast Cancer Models with a Distinct Mechanism of Action. Clin Cancer Res. 2017;23(24):7608–7620. PMID: 28974548.
- Puskas E, et al. Preclinical assessment of the selective androgen receptor modulator RAD140 to increase muscle mass and bone mineral density. Physiol Rep. 2025. PMID: 40680216.
- LiverTox: Clinical and Research Information on Drug-Induced Liver Injury — Selective Androgen Receptor Modulators. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases. NCBI Bookshelf NBK619971.
- Severe liver injury following use of RAD-140, a selective androgen receptor modulator, for body building. BMJ Case Rep / PubMed. PMID: 38444893.
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