What is RAD-140 (Testolone)?
RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM) developed to mimic the effects of testosterone without the associated androgenic side effects. It was originally created to help treat muscle wasting and age-related muscle degeneration, offering anabolic benefits without converting to estrogen or causing liver toxicity.
RAD-140 has rapidly become one of the most studied SARMs in performance research, particularly for its ability to stimulate lean muscle growth, increase strength, and support bone health—all while avoiding the suppression commonly seen with traditional anabolic steroids. Testolone’s tissue-selective mechanism makes it especially useful in research models where muscle development and safety are top priorities.
Chemical Properties

Chemical Name | RAD-140 (Testolone) |
CAS Number | 1182367-47-0 |
Molecular Formula | C20H16ClN5O2 |
Molecular Weight | 393.83 g/mol |
IUPAC Name | 2-chloro-4-[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]benzonitrile |
How Does RAD-140 Work?
RAD-140 binds selectively to androgen receptors in skeletal muscle and bone tissues, promoting anabolic activity without affecting other organs like the prostate or liver. It is designed to mimic the effects of testosterone with a higher safety profile, offering muscle-building potential without aromatization to estrogen or DHT.
Its strong binding affinity and selective activation help it deliver powerful results in lean muscle development and performance enhancement, which has made it a staple in strength- and mass-focused studies.
Potential Benefits Of RAD-140 Testolone
- Muscle Mass Gains: Research models show accelerated lean muscle growth, particularly in bulking cycles.
- Strength Enhancement: Noted improvements in power output and resistance training performance.
- Fat Reduction: Supports fat oxidation while preserving muscle, making it ideal for recomposition studies.
- Bone Health: May improve bone mineral density and joint support in aging or post-injury recovery models.
Clinical Research & Findings
RAD-140 has demonstrated impressive anabolic effects in preclinical studies, with subjects showing significant increases in lean body mass and strength without toxic effects on the liver or cardiovascular system. Animal studies also note its potential neuroprotective properties, mimicking the protective effects of testosterone in the brain. Its favorable safety and efficacy profile have positioned it as one of the most promising SARMs in muscle-related research fields.
RAD-140 Testolone Dosage Guide
Testolone is often dosed once daily due to its long half-life, with a typical range of 10–20mg per day in research applications. Its potent nature makes it advisable to start at a lower dose to assess response. RAD-140 is often used in 8–12 week research cycles, with some advanced protocols extending up to 16 weeks.
Because RAD-140 may suppress natural testosterone production at higher doses, researchers often follow cycles with post-cycle therapy (PCT) protocols to restore hormonal balance in test subjects.
Here’s a quick breakdown by goal:
-
Bulking (Max Muscle Growth):
15–20mg per day for 8–12 weeks -
Recomposition (Muscle + Fat Loss):
10–15mg per day for 8–10 weeks -
Strength Focus:
10mg per day for 6–8 weeks
Stacking RAD-140 With Other SARMs
“Can RAD-140 be combined with other SARMs?” Yes. RAD-140 is often stacked for advanced results in lean mass and strength research protocols. Its versatility makes it ideal for both standalone and stacked use.
Here are three popular combinations:
- Ligandrol (LGD-4033): For extreme muscle building phases, this stack amplifies anabolic output.
- Ibutamoren (MK-677): Enhances recovery, sleep, and growth hormone support alongside RAD-140’s anabolic power.
- Cardarine (GW-501516): Supports endurance and fat loss while preserving strength and muscle tissue.
FAQs
Is RAD-140 legal?
Yes. RAD-140 is legal to purchase for research purposes and is not classified as a controlled substance in Canada. It is not approved by the FDA for human consumption.
Does RAD-140 cause testosterone suppression?
In higher doses or longer cycles, RAD-140 may cause temporary suppression of natural testosterone production. PCT is recommended following research protocols.
How long is the half-life of RAD-140?
RAD-140 has a long half-life of approximately 16–20 hours, making once-daily dosing sufficient in most test subjects.
What form does this product come in?
This product is available in powder and liquid form with ≥98% purity, suitable for validated laboratory research applications.
Disclaimer
For laboratory use only. Not for human or veterinary use.
This material is intended strictly for research purposes under controlled laboratory conditions. It is the buyer’s responsibility to ensure legal and ethical use in accordance with institutional, local, and federal guidelines.
Always wear proper safety equipment and follow appropriate handling procedures.
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