Description
What is PT-141?
PT-141 (Bremelanotide) is a synthetic peptide designed to address sexual dysfunction through central nervous system pathways. Unlike PDE5 inhibitors that increase blood flow, PT-141 works by activating melanocortin receptors in the brain, which directly influence arousal and desire. This unique mechanism makes PT-141 a novel option for research into both male and female sexual health.
How Does PT-141 Work?
PT-141 targets melanocortin-4 receptors in the hypothalamus, stimulating pathways associated with libido. By bypassing vascular mechanisms, it can increase sexual desire in research subjects even when traditional ED medications are ineffective. This central action is why PT-141 has been studied as a treatment for hypoactive sexual desire disorder (HSDD) and erectile dysfunction (ED).
Chemical Properties
| Chemical Name | Bremelanotide |
| CAS Number | 189691-06-3 |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.2 g/mol |
| IUPAC Name | Ac-Nle-Asp-His-D-Phe-Arg-Trp-D-Phe-Lys-OH |
Potential Benefits of PT-141
- Increased Libido: Direct activation of sexual arousal pathways.
- Improved Intimacy: Supports closer relationships through enhanced desire.
- Alternative to PDE5 Inhibitors: May work where traditional ED drugs fail.
- Applicable to Both Men and Women: Broad research use across genders.
Clinical Research & Findings
Clinical studies have shown PT-141 to be effective in enhancing libido and sexual performance, particularly in individuals unresponsive to PDE5 inhibitors. Research highlights include improvements in arousal for both men and women, rapid onset of effects, and its role in expanding treatment options beyond vascular-based therapies.
Dosage & Research Protocols
- Standard Research Dose: 1–2 mg subcutaneous injection
- Timing: 30–60 minutes before desired effect
- Frequency: Used intermittently (not daily)
Research protocols recommend conservative use due to potency. Nausea and flushing are the most commonly reported side effects. Long-term safety data is limited.
FAQs
Is PT-141 legal in Canada?
Yes. PT-141 is legal for research use in Canada but is not approved for human consumption.
How is PT-141 administered?
Research protocols involve subcutaneous injection, typically in small doses.
Does PT-141 work for both men and women?
Yes. Studies suggest PT-141 may enhance libido in both men and women.
What form does PT-141 come in?
It is provided in lyophilized powder form with ≥98% purity for research use.
Disclaimer
For laboratory use only. Not for human or veterinary use.
This peptide is intended strictly for research under controlled laboratory conditions. Buyers are responsible for ensuring legal and ethical compliance with institutional, local, and federal regulations.

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