MK-677 – Ibutamoren

What is Ibutamoren (MK-677)?

Ibutamoren, also known as MK-677, is a growth hormone secretagogue that mimics the action of ghrelin and stimulates natural growth hormone (GH) and insulin-like growth factor 1 (IGF-1) production. Originally developed for treating muscle wasting, obesity, and osteoporosis, Ibutamoren has gained popularity in the research community for its potential to enhance recovery, improve sleep quality, and promote lean muscle mass.

Unlike traditional anabolic compounds, MK-677 does not suppress testosterone or interfere with the body’s hormonal balance. Instead, it works by encouraging the body to naturally elevate GH and IGF-1 levels—making it a powerful tool in studies focused on long-term muscle development and anti-aging.

Chemical Properties

How Does Ibutamoren Work?

Ibutamoren stimulates the ghrelin receptor in the brain, which in turn promotes the secretion of growth hormone and IGF-1. This results in elevated serum levels without altering cortisol or testosterone production. The result is a sustained release of GH over time, leading to potential benefits in recovery, body composition, and overall vitality.

Because it does not suppress the hypothalamic-pituitary-gonadal (HPG) axis, Ibutamoren is often included in long-term research cycles where hormonal stability is important.

Potential Benefits Of MK-677 Ibutamoren

• Increased Muscle Mass: May stimulate lean tissue growth by boosting endogenous GH and IGF-1 levels.
• Improved Recovery: Faster muscle repair and healing reported in research models.
• Deeper Sleep: Linked to enhanced REM and deep sleep cycles, which may support recovery and cognitive performance.
• Fat Loss Support: Potential for improved metabolic rate without catabolism of lean mass.

Clinical Research & Findings

Ibutamoren has been studied in various human and animal trials, showing notable increases in growth hormone and IGF-1 levels over sustained periods without significant side effects. One study noted a GH spike within 60 minutes of administration, with levels remaining elevated for up to 24 hours. Additional studies report improved sleep quality, enhanced nitrogen retention, and better skin elasticity in aging subjects.

MK-677 Ibutamoren Dosage Guide

Using MK-677 is straightforward and is often compared to taking a once-daily supplement. The recommended research dosage ranges from 10–25mg per day. Ibutamoren’s long half-life allows for convenient once-daily administration with or without food. Due to its GH-releasing properties, dosing before sleep is commonly used in performance-based protocols to enhance recovery.

Researchers are advised not to exceed 25mg per day for extended periods, as higher doses have shown diminishing returns and increased water retention in some models. A 12–24 week cycle is generally observed for long-term benefits, especially in studies focused on muscle hypertrophy or anti-aging.

Here’s a quick breakdown by goal:

• Bulking (Lean Muscle Gains):
  20–25mg per day for 16–24 weeks

• Anti-Aging & Wellness:
  10–15mg per day for 12+ weeks

• Recovery & Sleep Support:
  10–20mg before bed for 8–12 weeks

Stacking Ibutamoren With Other SARMs

“Can MK-677 be combined with other SARMs?” Absolutely. Ibutamoren is a popular choice in stack protocols thanks to its growth hormone-stimulating properties and hormonal neutrality.

Here are three ideal stack combinations for MK-677:

1. RAD-140 (Testolone): Combine with MK-677 to amplify strength and mass gains during bulking cycles.
2. Ligandrol (LGD-4033): This stack may support full-body recomposition while enhancing recovery time between workouts.
3. Ostarine (MK-2866): A mild cycle pairing for cutting or muscle preservation with added recovery benefits.

FAQs

Is Ibutamoren legal?

Yes. Ibutamoren is legal to purchase for research purposes and is not a banned substance under Canadian law. It is not approved by the FDA for human consumption or therapeutic use.

Does MK-677 suppress natural testosterone?

No. Ibutamoren does not affect the body’s androgen system and has not been shown to suppress testosterone levels, making it suitable for long-term studies.

How long is the half-life of Ibutamoren?

Research shows a half-life of approximately 24 hours, supporting convenient once-daily dosing in clinical and preclinical protocols.

What form does this product come in?

This product is available in powder and liquid form with ≥98% purity, suitable for validated laboratory research applications.

Disclaimer

For laboratory use only. Not for human or veterinary use.

This material is intended strictly for research purposes under controlled laboratory conditions. It is the buyer’s responsibility to ensure legal and ethical use in accordance with institutional, local, and federal guidelines.

Always wear proper safety equipment and follow appropriate handling procedures.