LGD-4033 – Ligandrol

What is Ligandrol (LGD-4033)?

Ligandrol, also known as LGD-4033, is a non-steroidal selective androgen receptor modulator (SARM) originally developed to combat muscle wasting and osteoporosis. It selectively binds to androgen receptors in muscle and bone tissue, helping stimulate lean muscle growth without the harsh side effects of traditional anabolic steroids.

Due to its high anabolic potency, favorable safety profile, and excellent oral bioavailability, LGD-4033 has become one of the most studied SARMs in both medical and performance research settings. It is widely considered one of the best all-around SARMs for size, strength, and recomposition-focused studies.

Chemical Properties

How Does LGD-4033 Work?

Ligandrol works by selectively binding to androgen receptors in skeletal muscle and bone tissue. Once bound, it stimulates anabolic activity, promoting lean muscle growth and preventing catabolism during calorie deficits. Unlike anabolic steroids, LGD-4033 does not convert to DHT or estrogen, reducing the risk of hair loss, gynecomastia, and water retention in research models.

Its tissue-specific selectivity allows for strong anabolic effects with minimal androgenic impact on other organs, such as the prostate.

Potential Benefits Of LGD-4033 Ligandrol

• Lean Muscle Growth: Among the most effective SARMs for adding size and strength in short cycles.
• Body Recomposition: Helps retain muscle during cutting while accelerating fat loss.
• Bone Support: Potential increases in bone mineral density make it useful in osteopenia/osteoporosis research.
• No Aromatization: No conversion to estrogen, minimizing side effects like water retention.

Clinical Research & Findings

In human clinical trials, LGD-4033 has demonstrated the ability to increase lean body mass significantly without affecting prostate size or hormone markers adversely. A 21-day trial showed subjects gaining over 1 kg of muscle with no serious adverse effects. Its consistent results and low toxicity profile have made it one of the most trusted SARMs for muscle mass studies.

LGD-4033 Ligandrol Dosage Guide

The recommended research dosage for Ligandrol ranges from 5–10mg per day, depending on the goal and subject tolerance. It has a half-life of approximately 24–30 hours, allowing for once-daily dosing. Most research cycles last between 8–12 weeks, though advanced protocols may extend up to 16 weeks with proper monitoring.

Due to its strength, LGD-4033 may suppress endogenous testosterone at higher doses or longer durations. A post-cycle therapy (PCT) is recommended after completion of the research protocol.

Here’s a quick breakdown by goal:

• Bulking (Mass & Size Gains):
  10mg per day for 10–12 weeks

• Recomposition (Fat Loss + Muscle Gain):
  5–10mg per day for 8–10 weeks

• Strength & Recovery:
  5mg per day for 6–8 weeks

Stacking LGD-4033 With Other SARMs

“Can LGD-4033 be stacked with other SARMs?” Absolutely. Ligandrol is highly versatile and stacks well in both bulking and recomposition research protocols.

Here are three strategic stack combinations:

1. RAD-140 (Testolone): Great for maximizing strength and muscle density during mass cycles.
2. Ibutamoren (MK-677): Enhances GH levels and recovery, making this stack ideal for lean gains and joint support.
3. Ostarine (MK-2866): A milder combination that supports joint integrity and muscle preservation during calorie deficits.

FAQs

Is Ligandrol legal?

Yes. Ligandrol is legal to purchase for research purposes in Canada. It is not a controlled substance but is not approved by the FDA for human consumption.

Does LGD-4033 suppress testosterone?

Yes, in higher doses or long cycles, LGD-4033 may suppress testosterone. A proper PCT protocol is recommended post-cycle.

How long is the half-life of LGD-4033?

LGD-4033 has a half-life of approximately 24–30 hours, supporting convenient once-daily dosing.

What form does this product come in?

This product is available in powder and liquid form with ≥98% purity, suitable for validated laboratory research applications.

Disclaimer

For laboratory use only. Not for human or veterinary use.

This material is intended strictly for research purposes under controlled laboratory conditions. It is the buyer’s responsibility to ensure legal and ethical use in accordance with institutional, local, and federal guidelines.

Always wear proper safety equipment and follow appropriate handling procedures.