Cardarine – GW-501516

What is Cardarine (GW-501516)?

Cardarine, also known as GW-501516, is a peroxisome proliferator-activated receptor delta (PPARδ) agonist developed to enhance endurance, improve fat metabolism, and support cardiovascular health. Although often grouped with SARMs, Cardarine is not a SARM—it does not bind to androgen receptors and has no hormonal activity.

Originally researched for its potential in treating obesity, diabetes, and metabolic syndrome, GW-501516 has become a key focus in performance-based research for its remarkable effects on endurance, fat loss, and lipid regulation.

Chemical Properties

How Does Cardarine Work?

Cardarine activates the PPARδ pathway, a key regulator of fatty acid oxidation, energy output, and mitochondrial activity. By stimulating these receptors, GW-501516 enhances the body’s ability to burn fat as fuel, boost endurance, and improve cholesterol profiles in research models.

Unlike hormone-based compounds, Cardarine does not affect testosterone, estrogen, or cortisol levels. Its non-suppressive nature makes it especially useful in studies focused on endurance or as part of bridging or cutting research protocols.

Potential Benefits Of GW-501516 Cardarine

• Enhanced Endurance: Often referred to as “exercise in a bottle,” Cardarine may increase stamina and reduce fatigue.
• Fat Loss: Supports fat metabolism without impacting muscle tissue or hormone levels.
• Improved Lipid Profile: Research suggests potential reductions in LDL and increases in HDL cholesterol.
• No Testosterone Suppression: Non-hormonal and does not require PCT.

Clinical Research & Findings

Cardarine has been shown in animal studies to significantly increase endurance and metabolic performance. In one study, mice treated with GW-501516 were able to run nearly twice as far as untreated mice. Additional research showed improved insulin sensitivity and a reduction in triglycerides. Though human clinical use is not approved, its profile remains a subject of active research in sports science and metabolic health.

GW-501516 Cardarine Dosage Guide

Cardarine is typically dosed at 10–20mg per day in research protocols. With a half-life of roughly 16–24 hours, it is commonly administered once daily. Standard research cycles range from 6–12 weeks.

As a non-hormonal compound, Cardarine does not require post-cycle therapy (PCT) and is often used in between or alongside SARM research protocols to preserve endurance and fat-burning benefits.

• Endurance Performance: 10–20mg per day for 8–12 weeks
• Fat Loss Support: 15–20mg per day for 6–10 weeks
• Stacking with SARMs: 10mg per day for duration of cutting or recomposition cycle

Stacking Cardarine With Other SARMs

“Can GW-501516 be combined with other SARMs?” Yes. Cardarine is a common addition to both cutting and recomposition stacks due to its fat-burning and endurance-enhancing effects—without hormonal disruption.

Popular stack options include:

1. Andarine (S4): Targets lean muscle preservation while Cardarine boosts fat loss.
2. Ligandrol (LGD-4033): A bulking-friendly combo with endurance and cardiovascular support.
3. Ostarine (MK-2866): Ideal for recomposition stacks prioritizing joint and muscle support.

FAQs

Is Cardarine legal?

Yes. Cardarine is legal to purchase for research use in Canada and many other countries. It is not FDA-approved for human consumption.

Does GW-501516 suppress testosterone?

No. Cardarine is a non-hormonal compound and does not affect testosterone production or require PCT.

How long is the half-life of Cardarine?

Cardarine has a half-life of approximately 16–24 hours, supporting once-daily dosing in most protocols.

What form does this product come in?

This product is available in powder and liquid form with ≥98% purity, suitable for validated laboratory research applications.

Disclaimer

For laboratory use only. Not for human or veterinary use.

This material is intended strictly for research purposes under controlled laboratory conditions. It is the buyer’s responsibility to ensure legal and ethical use in accordance with institutional, local, and federal guidelines.

Always wear proper safety equipment and follow appropriate handling procedures.