Andarine – S4 S-40503

What is Andarine (S4)?

Andarine, also known as S4, is a selective androgen receptor modulator (SARM) originally developed to treat muscle wasting and osteoporosis. It has gained attention in research communities for its potential to promote lean muscle development and reduce body fat—without the severe side effects of anabolic steroids.

S4 is one of the most extensively researched SARMs in Canada, as well as the rest of the world. The majority of these SARMs studies have been to determine the benefits and side effects of Andarine as a treatment for rapid muscle deterioration diseases like osteoporosis. These experiments found that S4 (Adnarine) not only maintains lean muscle, it actually promotes growth of those muscles while taking it as well. One such study saw muscle mass increase by 1-1.5 kg in just 90 days, without any changes in the subject’s exercise routine or diet. This same study also saw a decrease in body fat thanks to the fact that S4 Andarine breaks down stored fats within the body. Throughout the studies, there have been no reports of any concerning side effects from S4 Andarine, making it a very safe SARM for beginners!

Chemical Properties

How Does Andarine Work?

Andarine selectively binds to androgen receptors in skeletal muscle and bone tissues. It may stimulate anabolic activity in muscle while simultaneously preventing bone degradation. Unlike traditional steroids, it does not convert to DHT or estrogen, which may reduce unwanted side effects in research models.

Its partial agonist behavior makes Andarine uniquely suitable for cutting-phase studies, offering potential fat loss support without the extreme suppression seen with other SARMs.

Potential Benefits Of S4 Andarine

• Lean Muscle Preservation: Andarine may help maintain or grow muscle during calorie-restricted phases.
• Fat Oxidation: May increase metabolic activity and promote fat loss in tested organisms.
• Improved Bone Strength: Research suggests enhanced bone mineral density, beneficial in models of osteoporosis.
• Hardening Effect: Often studied for its potential to create a “dry,” vascular look without water retention.

Clinical Research & Findings

Preclinical research on Andarine demonstrates promising anabolic effects in muscle tissue and moderate anti-catabolic properties. Studies have noted its ability to reduce fat mass while preserving lean body composition. Although originally explored for medical conditions like muscle wasting, Andarine has also been evaluated in sports science labs for its body recomposition potential.

Andarine (S-40503) Dosage Guide

Taking Andarine (S4) is simple and convenient—just like your daily supplement routine. For men, the recommended dosage ranges from 25–75mg per day, while for women, a lower range of 10–25mg per day is advised. Since response to SARMs can vary by individual, it’s best to start with a low dose and gradually increase based on your body’s tolerance and performance feedback. For tailored guidance, we recommend speaking with a healthcare professional familiar with SARMs.

While Andarine is well-tolerated, using more than 75mg per day beyond 12–16 weeks is not recommended. Although higher doses don’t typically increase side effects, they may suppress free testosterone levels post-cycle and result in diminishing returns.

Here’s a quick breakdown by goal:

• Strength Gain (Minimal Muscle Mass Gains):
  50+mg per day for 6–8 weeks

• Body Recomposition (Lean Muscle + Fat Loss):
  50–75mg per day for 4–8 weeks

• Cutting (Fat Loss While Preserving Muscle):
  50mg per day for 6–8 weeks

Stacking Andarine With Other SARMs

“Can S-40503 be combined with other SARMs?” The answer is YES! Andarine can be “stacked” with other SARMs to maximize your results.

Let’s consider three potential stack mates for S4X: Stenabolic (SR9009), Ibutamoren (MK-677), and Ostarine (MK-2866).

1. Stenabolic (SR9009): Known for its energy-boosting capabilities, when paired with S4X’s muscle-building effects, this duo can help amplify your workout performance.
2. Ibutamoren (MK-677): Ibutamoren, designed to increase growth hormone levels, aids muscle growth and recovery. When combined with S4X, these two create a powerful team that could elevate your muscle growth journey.
3. Ostarine (MK-2866): Ostarine is renowned for its muscle and bone-strengthening properties. When stacked with S4X, this duo could lead to impressive gains in strength and muscle size.

FAQs

Is Andarine legal?

Yes. Andarine is legal for sale as a research chemical. It is not approved by the FDA for human consumption or therapeutic use.

Can Andarine be combined with other SARMs?

In research settings, Andarine is often studied alongside compounds like Ostarine (MK-2866) or Cardarine (GW-501516) to explore synergistic effects on cutting and endurance outcomes.

How long is the half-life of Andarine?

Research indicates a half-life of approximately 4–6 hours, suggesting twice-daily administration in test protocols may yield more consistent serum levels.

What form does this product come in?

This product is available in powder and liquid form with ≥98% purity, suitable for validated laboratory research applications.

Disclaimer

For laboratory use only. Not for human or veterinary use.

This material is intended strictly for research purposes under controlled laboratory conditions. It is the buyer’s responsibility to ensure legal and ethical use in accordance with institutional, local, and federal guidelines.

Always wear proper safety equipment and follow appropriate handling procedures.